Due to 12 y.o. Anna's asthma, she's sent to stay with relatives of her guardian in the Japanese countryside. She likes to be alone, sketching. She befriends Marnie. Who is the mysterious, blonde Marnie.
On a journey to find the cure for a Tatarigami's curse, Ashitaka finds himself in the middle of a war between the forest gods and Tatara, a mining colony. In this quest he also meets San, the Mononoke Hime.